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The following was taken from 101 Mole Day Jokes!

  1. What did one mole say to the other?… We make great chemistry together.
  2. Why did Avogadro stop going to a chiropractor on October 24th?… He was only tense to the 23rd!
  3. How much does Avogadro exaggerate?… He makes mountains out of mole hills
  4. Why is it bad to tell mole jokes?… It’s mole-itically incorrect
  5. What did Avogadro get when he mixed ice cream, chocolate syrup, and milk together?… A chocolate Moletd
  6. What’s the mole’s favorite college football team?… The Florida State Semimoles
  7. What kind of fruit did Avogadro eat in the summer?… Watermolens
  8. How many guacs are in a bowl of guacamole?… Avocado’s number!
  9. Avogadro loved to watch MASH. Which character did he like most?… Father Molecahy
  10. What element do moles love to study in chemistry?… Molybdenum
  11. What does Avogadro put in his hot chocolate?… Marsh-mole-ows!
  12. How does Avogadro write to his friends?… By e-mole!
  13. What do you call a tooth in a glass of water?… A one molar solution.
  14. What did Avogadro collect at the seashore?… mole-uscs
  15. Why is Avogadro so rich?… He’s a multi-mole-ionare!
  16. What did Avogadro call his church services?… Molar Mass
  17. Why was there only one Avogadro?… When they made him, they broke the Moled
  18. What kept Avogadro in bed for two months?… Moleonucleosis
  19. What did Avogadro invent for his wife to use as a night cream?… Oil of Molay
  20. Why is Avogadro in love with Cindy Crawford?… She’s his favorite super-mole-dle (and she has a mole).
  21. What did the generous mole say when his friends crashed his party?… The mole the merrier!
  22. What are the moles’ favorite line from the Wizard of Oz?… “I’m mole-ting, I’m mole-ting.”
  23. If a mole of moles were digging a mole of holes, what would you see?… A mole of molasses!
  24. What kind of test do student moles like best?… Mole-tiple choice.
  25. What is Avogadro’s favorite kind of music?… Rock ‘N’ Mole
  26. What happens when a mole bites a dog?… He becomes Moleicious!
  27. Why does the chemist like going to the zoo?… To see the animoles.
  28. What did Avogadro teach his students in math class?… Moletiplication
  29. Which tooth did Avogadro have pulled?… One of his molars.
  30. Who is the the mole’s favorite actor?… Mole Gibson
  31. Why are moles bad at counting?… Because they only know one number.
  32. What’s the mole’s favorite brand of soda?… Coca-Mola.
  33. What’s the mole’s favorite Disney Movie?… The Little Molemaid
  34. Why do moles love music from the 60’s?… Because of Moletown
  35. Why are moles always on the phone?… Because they love moleble devices.
  36. Why do moles love Tyra Banks?… Because she’s on America’s Next Top Moledel
  37. What was Avogadro dressed as when he went to the masquerade ball?… an avacado
  38. What was Avogadro full of?… Molar energy or 6 × 1023 particles
  39. Why are moles always eating?… Because they’re molenourished.
  40. How did Avogadro get through the desert?… on a camole
  41. On which American mountain was Avogadro’s face carved in stone?… Mount Rushmole
  42. What was Avogadro’s favorite board game?… Moleoply
  43. Who was Avogadro’s favorite singing group?… The Moleing Stones
  44. Who was Avogadro’s favorite composer?… Moles art
  45. How would you have described Avogadro’s room while he was a teenager?… a Molar Mess
  46. What was Avogadro’s best day in golf?… when he got a mole-in-one
  47. What is Avogadro teaching his astronomy class about?… the molar system
  48. How did Avogadro help his team win the soccer playoffs?… he scored the winning mole
  49. Why did people say Avogadro was lazy?… They said he was slow as moleasses
  50. What are moles made of?… molecules